Nkana will welcome Pedro in the first-leg encounter on Saturday at the Nkana Stadium in Kitwe, Zambia.
Pedro, who are undefeated in this year’s Confederation Cup, are looking to reach the group stage for the first time.
Jani Tarek, the San Pedro head coach, is expecting a tough match against Nkana, who finished second in the 1990 CAF Champions League.
San Pedro were impressive in the second round when they eliminated 1994 CAF Winners’ Cup Champions and 2011 CAF Confederation Cup group stage campaigners DC Motema Pembe of DR Congo whom they held 1-1 away in Kinshasa and later beat 2-0 in Abidjan on December 22.
“Motema Pembe and Nkana are both big teams but this our first experience in the Confederation Cup,” Jarek said.
“But we will try and make sure we have a good match. I know it will be a difficult match and Nkana is a very good team but we will try our very best.”